| This is a newsletter from NextBioForm, a centre coordinated by RISE with the goal to deliver better formulations for biopharmaceuticals. In the long-term perspective, our goal is to create stable biopharmaceuticals that will improve the quality of life for patients. |
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| Systems that contain both proteins and surfactants are ubiquitous in daily products, from efficient detergents and cosmetic products to life-saving therapeutic formulations. Surfactants are amphiphilic molecules composed of both water-loving and water-hating moieties. They are routinely added to liquid pharmaceutical formulations to enhance the stability of the drug, but these can also trig the degradation of the protein. Although protein-surfactant systems have been studied for decades, a general mechanistic understanding is still missing, and their inherent complexity requires novel approaches to further investigate these systems. |
| Read the full article here |
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| The presence of an even small amount of water in the freeze-drying biotherapeutic formulations can have a negative impact on their long-term stability and storage. Using a synchrotron-based technique, researchers from MAU together with partners within NBF (SOBI, RISE, MAXIV) can now provide a new way to extract the structural information of proteins in a solid state and during the rehydration, which is an important piece of the puzzle to better understanding the relationship between the moisture content and protein stability in solid-state formulations. |
| Read the full article here |
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We have measured SAXS on standard samples, salt and protein, and processed them with the software data pipeline. NextBioForm continues to develop this work during the autumn. Next year the first accepted research proposals will take place on CoSAXS.
For more information on how to send in a proposal (deadline 13/10) visit the MAX IV website or contact Christopher Söderberg.
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Since our last newsletter, NextBioForm has recruited three new doctoral students:- Amanda Västberg, RISE/LU, working with protein at interfaces linked to physical stability of the system,
- Daniel Osanlóo, RISE/LU, working with alternative drying technologies for biologics,
- and Zandra Gidlöf, RISE/LU (financed by SSF), working with novel delivery form of probiotics for microflora modulation.
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| Read more about our newest additions to the team. |
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